Yunnan Baiyao Group Co., Ltd.Yunnan Baiyaoablets 4g

Indications of Yunnan Baiyao

1. Traumatic Injuries and Soft Tissue Damage

• Primary Conditions:
  • Contusions, sprains, strains, and blunt trauma (e.g., falls, sports injuries) with:
    • Swelling, bruising (ecchymosis), local tenderness, and limited mobility.
• Therapeutic Effects:
  • Accelerates blood clotting to stop internal/external bleeding; reduces inflammation via inhibiting pro-inflammatory cytokines (e.g., TNF-α, IL-6).
• Clinical Use Cases:
  • Ankle sprains, muscle contusions, and post-surgical wound healing (applied topically or orally as adjuvant therapy).

2. Hemorrhagic Disorders

• Internal Bleeding:
  • Gastrointestinal Bleeding: Peptic ulcer hemorrhage, esophageal variceal bleeding (as adjunct to standard care), characterized by hematemesis or melena.
  • Pulmonary Hemorrhage: Coughing up blood (hemoptysis) in tuberculosis, bronchiectasis, or pneumonia (TCM pattern: "blood heat" or qi deficiency leading to blood recklessness).
  • Gynecological Bleeding: Dysfunctional uterine bleeding, menorrhagia (excessive menstrual flow), and metrorrhagia (irregular bleeding), especially with dark, clotted blood.
• External Bleeding:
  • Wounds, incisions, abrasions, and lacerations (topical application stops bleeding and promotes granulation); first aid for traumatic hemorrhage (e.g., cuts, puncture wounds).

3. Bone and Joint Disorders

• Osteoarthritis and Rheumatism:
  • Chronic joint pain, stiffness, and swelling (TCM pattern: "wind-damp-cold" obstruction), especially in knees, wrists, and ankles.
• Fractures and Dislocations:
  • As adjuvant therapy to promote bone healing and reduce post-reduction swelling; used orally to invigorate blood circulation and remove stasis.
• Spinal Disorders:
  • Lumbar muscle strain, herniated discs, and sciatica with localized blood stasis (symptoms: radiating pain, numbness, limited flexion/extension).

4. Gynecological and Obstetric Applications

• Menstrual Disorders:
  • Dysmenorrhea (painful menstruation) with dark blood and clots; irregular cycles due to blood stasis or qi stagnation.
• Postpartum Recovery:
  • Reduces lochia (postpartum vaginal discharge) duration and alleviates abdominal pain; promotes uterine involution.
• Miscarriage Prevention:
  • In traditional practice, used for threatened miscarriage with spotting (TCM pattern: blood stasis without impairing the fetus), though modern evidence is limited.

5. Dental and Oral Conditions

• Periodontal Disease:
  • Gingivitis, periodontitis with bleeding gums, swelling, and bad breath (topical application or oral administration to reduce inflammation).
• Oral Ulcers:
  • Recurrent aphthous stomatitis (canker sores), especially those associated with heat-toxicity or blood stasis.
• Toothache:
  • Traumatic or inflammatory tooth pain (e.g., after extraction), used topically as a paste for analgesia.

6. Adjunctive Therapy for Cancer-Related Symptoms

• Symptom Management:
  • Reduces tumor-related bleeding (e.g., in gastrointestinal or gynecological cancers) and alleviates pain from bone metastases (evidence primarily from case reports and preclinical studies).
• Chemotherapy Support:
  • Some studies suggest it may mitigate chemotherapy-induced thrombocytopenia (low platelet count), though rigorous clinical trials are needed.

Ingredient Synergy and Mechanism

Administration and Safety Considerations

• Routes of Administration:
  • Oral: Capsules or powder (0.25–0.5 g, 4 times daily); children: 1/4–1/2 adult dosage, based on age.
  • Topical: Ointment or powder applied directly to clean wounds; avoid open cavities (e.g., eyes, nostrils).
• Contraindications:
  • Hypersensitivity to ingredients; severe hepatic/renal dysfunction; pregnant women (risk of uterine contraction); avoid during the first trimester.
• Precautions:
  • Do not use for severe arterial bleeding (requires medical intervention); discontinue if allergic reactions (rash, itching) occur; limit alcohol consumption during use (increases bleeding risk).

Clinical Evidence and Limitations

• Supporting Research:
  • Randomized trials show Yunnan Baiyao reduces bleeding time in dental surgeries and improves recovery in acute soft tissue injuries.
  • In gynecology, it decreases menstrual blood loss in menorrhagia compared to placebo.
• Limitations:
  • Mechanistic studies are limited, especially for complex conditions like cancer; international clinical guidelines lack consensus on its use outside trauma and hemorrhages.
• Drug Interactions:
  • May interact with anticoagulants (warfarin, aspirin) or antiplatelet drugs; monitor coagulation parameters if co-administered.