Guangdong Huazhou Chinese Medicine Factory Pharmaceutical Co., Ltd Huoxiang Zhengqi Mixture Xiangxue 10ml*10 tablets

Indications of Huoxiang Zhengqi Mixture (Xiangxue)

1. Gastrointestinal Disorders (Primary Indications)

• Syndrome: Internal Dampness with Qi Stagnation
  • Manifestations: Epigastric fullness, nausea, vomiting, diarrhea, abdominal pain, loss of appetite, and a sticky sensation in the mouth.
• Specific Conditions:
  • Acute Gastroenteritis: Triggered by cold, greasy diet, or bacterial infection (e.g., E. coli), especially with watery stools, vomiting, and abdominal distension.
  • Food Poisoning (Mild to Moderate): Nausea and diarrhea due to ingesting unclean or cold foods (TCM pattern: "dampness-toxin" invading the spleen-stomach).
  • Functional Dyspepsia: Postprandial fullness, belching, and poor appetite without organic lesions, associated with dampness obstructing the middle burner.

2. Exogenous Cold-Damp Syndrome (Seasonal Applications)

• Summer Dampness-Heat or Cold-Damp Environment
  • Common in:
    • Hot and humid weather (e.g., summer heatstroke with dampness), leading to dizziness, fatigue, nausea, and fever with chills.
    • Exposure to cold dampness (e.g., air conditioning abuse, wading in water), causing body aches, headache, and nasal congestion.
• Symptoms Addressed:
  • Headache, heavy sensation in the head, body soreness, mild fever, aversion to cold, stuffy nose, and thin white or greasy tongue coating.

3. Motion Sickness and Vestibular Disorders

• Nausea and Vomiting Induced by:
  • Travel (car, ship, plane), characterized by dizziness, cold sweats, and epigastric discomfort.
• Mechanism:
  • Regulates stomach qi descent and reduces inner ear fluid imbalance (TCM: calming the "upward rebellion of stomach qi").

4. Skin and Soft Tissue Infections (Topical Adjunct Use)

• Indications:
  • Mild eczema, tinea versicolor, or insect bites with damp-heat manifestations (redness, itching, exudation).
• Application Method:
  • Diluted mixture applied topically to reduce inflammation and dry exudates (not a primary treatment; used alongside standard dermatological care).

5. Adjunctive Therapy for Respiratory Symptoms

• Upper Respiratory Tract Infections (Limited Use):
  • Common cold with clear nasal discharge, cough, and chest tightness due to cold-dampness obstructing the lung qi.
• TCM Rationale:
  • "Lung and spleen are interrelated"; resolving dampness in the spleen helps dissipate phlegm in the lungs.

Ingredient Synergy and Mechanism

Administration and Safety Considerations

• Dosage and Usage:
  • Adults: 10–15 mL per dose, 2–3 times daily; shake well before use.
  • Children: 5–10 mL per dose, adjusted by age (consult a TCM practitioner).
  • Route: Oral administration; may be diluted with warm water to reduce bitterness.
• Contraindications:
  • Hypersensitivity to ingredients; severe vomiting or diarrhea leading to dehydration (requires intravenous rehydration); pregnant women (use with caution due to magnolia and pinellia).
• Precautions:
  • Avoid 生冷 (raw, cold), 油腻 (greasy) foods during treatment; discontinue if symptoms worsen after 3 days; not recommended for high fever (>38.5°C) or bloody diarrhea (seek medical attention).

Clinical Evidence and Limitations

• Supporting Research:
  • Randomized trials show Huoxiang Zhengqi Mixture reduces vomiting frequency and diarrhea duration in acute gastroenteritis compared to placebo.
  • In motion sickness, it improves nausea scores similar to dimenhydrinate in some studies, though evidence is moderate.
• Limitations:
  • Most trials are small-scale and conducted in China; mechanistic studies lack clarity on specific active components; international guidelines rarely reference it for gastrointestinal disorders.
• Drug Interactions:
  • May interact with antiemetics (additive effects); avoid alcohol (increases gastric irritation and conflicts with TCM principles).